Gropman Laboratory

About the Lab

The Gropman Laboratory focuses on inborn errors of metabolism and chromosome disorders. 

The two major categories of inborn errors studied are urea cycle disorders and mitochondrial disorders. The laboratory investigates brain biomarkers of injury using multimodal noninvasive technologies such as electroencephalogram (EEG), functional near infrared spectroscopy, magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to investigate alterations in neural circuitry and metabolism in these disorders. 

Andrea Gropman, M.D., is the principal investigator of the National Institutes of Health (NIH)-funded Urea Cycle Disorders Consortium (UCDC) and the site principal investigator of the North American Mitochondrial Disease Consortium (NAMDC). Both of these are part of the Rare Disease Clinical Research Network (RDCRN). Dr. Gropman oversees a Mitochondrial Center of Excellence at Children’s National Hospital. Her work in mitochondrial disorders also involves her role in the MitoEpiGen Program at George Washington University School of Medicine and Health Sciences, led by Anne Chiaramello, Ph.D. This project focuses on translational studies of promising therapeutics for patients with mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber hereditary optic neuropathy (LHON), two subcategories of mitochondrial disorders. 

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