Koutroulis Laboratory

About the Lab

The Koutroulis Laboratory focuses on sepsis and other severe infections and the development of a comprehensive research program that includes novel diagnostic and therapeutic protocols. We utilize an AI-based clinical decision support sepsis screening platform combined with serum biomarkers, and machine learning for early detection and treatment of pediatric sepsis to prevent severe organ dysfunction and failure. Additionally, the use of extracellular vesicles has shown promising results in partially reversing metabolic and immune abnormalities. Our goal is to target the deleterious energetic failure and inflammatory tissue damage that occur under septic conditions so we can achieve improved clinical outcomes.
  • Lab Focus Areas

    Immunology and Molecular Biology

    Artificial Intelligence and Predictive Analytics

    Metabolism and obesity

  • Partnerships

    Georgetown University
    Cincinnati Children’s Hospital
    Emory University
    UH Rainbow Babies & Children’s Hospital
    Johns Hopkins University
    Vivace Inc.

  • Contact

    Ioannis Koutroulis, M.D., Ph.D., M.B.A. Principal Investigator

Biomarker-enhanced Artificial Intelligence-Based Pediatric Sepsis Screening Tool Towards Early Recognition and Personalized Therapeutics

The goal of this award is to develop an artificial intelligence (AI)-based pediatric sepsis screening tool that can be routinely used in emergency departments to improve both early recognition and personalized treatment, known to be associated with reduced mortality in infected children.