About the Lab
The Rood Laboratory is working to apply the tools of cutting-edge proteomics to discover the functional biology of childhood brain tumors. Findings indicate that disease-specific proteins detected in brain tumor cells and cerebrospinal fluid can provide biological insight into the disease. These novel tumor-specific proteins can be essential for tumor cell survival and thus have the potential to be drug targets. In addition, given that they are abnormal and thus foreign to the body, they can be used as targets for T cell immunotherapy development. Lastly, because they are only created by an individual’s tumor cells, they can serve as biomarkers — measurable indicators of the presence or biological characteristics of the disease. Our lab is also investigating the role of DNA microsatellite repeats in predisposing an individual to develop a brain tumor.
Integrated proteogenomic characterization across major histological types of pediatric brain cancerFrancesca Petralia, Nicole Tignor, Boris Reva, Mateusz Koptyra, Shrabanti Chowdhury, Dmitry Rykunov, Azra Krek, Weiping Ma, Yuankun Zhu… *Adam C. Resnick,*Phillip B. Storm,*Brian R. Rood and *Pei Wang *co-corresponding authors Cell 23;183(7):1962-1985.e31 PMID: 33242424 December (2020)
Germline microsatellite genotypes differentiate children with medulloblastomaRivero-Hinojosa S, Kinney N, Garner HR, Rood BR Neuro-Oncology 22(1):152-162 (2019)
Proteomic analysis of medulloblastoma reveals functional biology with translational potentialRivero-Hinojosa S, Lau LS, Stampar M, Staal J, Zhang H, Gordish-Dressman H, Northcott PA, Pfister SM, Taylor MD, Brown KJ, Rood BR Acta Neuropathol Commun 6(1):48. DOI: 10.1186/s40478-018-0548-7 PMID: 29880060 June (2018)
Proteomic profiling of high risk medulloblastoma reveals functional biologyStaal, J., Lau, L., Zhang, H., Ingram, W., Hallahan, A., Northcott, P., Pfister, S., Wechsler-Reya, R., Rusert, J., Taylor, M., Cho, Y., Packer, R., Brown, K., Rood, BR. Oncotarget 10;6(16):14584-95. PMID: 25970789; PMCID: PMC4546489 June (2015)
Deciphering HIC1 control pathways to reveal new avenues in cancer therapeuticsRood BR, Leprince D Expert Opinion on Therapeutic Targets PMCID:PMC3683369 April (2013)