Nazarian Lab

About the Lab

Brain tumors are now contributing to the most cancer-related deaths in children. One of the deadliest tumors we face within pediatric neuro-oncology are diffuse midline gliomas (DMG). Most DMGs occur in the pons and are referred to as diffuse intrinsic pontine glioma (DIPG). Over 2,000 children and young adults are diagnosed with these tumors in the United States and Europe annually. Decades of research and clinical trials have not achieved any improvement in the clinical outcome for these patients and most die within a year from their initial diagnosis. Applying genomic-based technologies, we have made great progress in shedding light on the underlying molecular alterations of these tumors and today have a much better understanding that DMGs represent heterogeneous groups of tumors that require further stratification when developing new therapies.

PM derived preclinical models

Children with cancer predisposition syndromes, such as neurofibromatosis type 1 (NF1), are at greater risk for developing brain and other types of tumors. Although these tumors are often benign, some children require multiple treatment courses, and other children and young adults will have high-grade tumors that are much more difficult to treat. In order to gain a better understanding of the risk factors that are present in patients with more aggressive tumors, our lab is working to identify molecular and environmental/biological changes within the tumor and plasma that occur as tumors transition from low to high grade in patients with NF1.

Our team at Children’s National Research Institute is involved in conducting studies toward understanding mutations that drive tumors and the genomic landscape that can help to guide development of novel mechanisms for targeted therapies. The research knowledge from our lab comes as a direct result of parents donating specimens, judicious shepherding of these scarce resources by researchers, molecular characterization of tumors and development of preclinical models.