Tucker Pyle, MD, PhD, MSTR, FAA
- Director and Principal Investigator, GoRAD Laboratory
- Director, PROUD and Klinefelter Clinical Programs
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- MSTR, University of Pennsylvania, Philadelphia, PA, (2017-2021)
- Postdoc, Rare Mendelian Genetic Variation, Children's Hospital of Philadelphia, Philadelphia, PA, (2017-2021)
- Postdoc, Cancer Predisposition, University of Pennsylvania, Philadelphia, PA, (2015-2019)
- Fellowship, Medical Genetics and Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, (2016)
- Residency, Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, (2015)
- MD, University of Alabama at Birmingham, Birmingham, AL, (2003-2011)
- PhD, Human Genetics, University of Alabama at Birmingham, Birmingham, AL, (2003-2009)
- BA, Biochemistry, Smith College, Northampton, MD, (1996-2000)
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Tucker L.C. Pyle, MD, PhD, MSTR, is a clinical geneticist and physician scientist specializing in genetics of genitourinary (GU) differences and cancer. Dr. Pyle's training and background includes a PhD in mutation-specific drug development for Cystic Fibrosis, post-doctoral training in cancer predisposition syndromes and testicular germ cell tumor, and second post-doctoral training in gene discovery and variant interpretation in rare human variation.
Dr. Pyle’s research applies genomics and human models to understand vulnerability to genitourinary differences, infertility and germ cell tumor (GCT). Dr. Pyle's team, the GenitOurinary Rare Anatomic Differences (GORAD) Laboratory has identified and characterized clinical risk factors that predispose people to GCT by learning from and studying individuals diagnosed with this malignancy, as well as patients carrying a diagnosis of intersex traits and variations of sexual characteristics (also sometimes called differences of sex development). Dr. Pyle’s goal is to supply new tools that will facilitate improved care for people with I/VSC's.
Dr. Pyle’s clinical focus is diagnostic evaluation and care for individuals with I/VSC. Dr. Pyle directs the Children's National PROUD Clinic for people with I/VSCs. Dr. Pyle focuses on multidisciplinary integration, molecular diagnosis and cancer predisposition counseling for patients and their families. Dr. Pyle is also a specialist in X and Y chromosomes, and sees people clinically with these differences, including in the Prenatal Pediatrics Institute, the Turner Syndrome Program and as director of the Children's National Klinefelter (XXY) Program.