Our Research

Currently, we are investigating how candidate genes regulate prenatal viral clearance and neuronal survival. To achieve this, we use three unique and synergistic model systems to evaluate how expression of neurodevelopmental gene affects prenatal neuroviral susceptibility.

Experimental Systems

Cell and Tissue Culture Model

We use induced pluripotent stem cells, neural stem cells, and cerebral organoids to understand how human cells respond to a viral infection. We use these systems primarily to identify the key downstream regulatory pathways and cellular responses that regulate viral clearance and how infected cells are injured.

Pre-Clinical Model

We developed an immunocompetent prenatal pre-clinical model that replicates the type of brain injury seen in children infected with Zika virus. This system allows us to evaluate neuronal and placental histology and correlate these findings with developmental outcomes after birth. We evaluate outcomes by performing neurobehavioral testing for motor, social, and cognitive function.

Populational Genomics System

We work closely with the Prenatal Infection and Neurodevelopmental Genetics (PING) Consortium to understand how genetic variants in people affect risk for brain injury. Combined with the model systems above, we can synergistically identify new genes that might contribute risks and evaluate known genes of interest.