About the Lab

The Advanced Physiological Signals Processing Lab (APSL) develops and translates quantitative methods for the analysis of physiological signals from fetuses, newborns and critically ill infants. Under the direction of Rathinaswamy Bhavanandhan (RB) Govindan, PhD, MS, the lab supports high-quality signal acquisition, automated analysis pipelines and end-user training. The team collaborates across critical care units, engineering, neuroscience, imaging and biostatistics to transform complex continuous physiological data into interpretable metrics that advance research and ultimately support clinical decision-making.

Mission

To identify antecedents of critical events, including brain injury, through the analysis of physiological signal patterns and translate these insights into tools that support informed clinical decision-making by intensivists.

Vision

To identify early predictors of brain injury in high-risk fetuses and critically ill newborns, enabling earlier diagnosis, intervention and improved outcomes.

Approach and Collaboration

APSL studies multimodal physiological signals collected continuously at the bedside. Its analytic work includes heart-rate variability, brain function and directed brain connectivity, cerebral oximetry and cerebral pressure autoregulation, circadian rhythms and sleep-state physiology. The lab collaborates with intensivists in neurology, Neonatal Intensive Care Unit and Cardiac Intensive Care Unit.

Selected Completed Grant Support

Impaired Brain Development in a Premature Ex-utero Environment (project period: March 12, 2020–February 28, 2025). Principal Investigators: Adré du Plessis, MBChB, and Catherine Limperopoulos, PhD. Dr. Govindan served as Co-Investigator.